College football odds, picks, predictions: USC-Indiana, Texas-LSU lead Week 11

Key Points:

• Week 11 in college football features crucial matchups across Power Four conferences, impacting both league standings and the College Football Playoff (CFP) race, with key games including USC vs. Indiana, Wake Forest vs. SMU, and Texas vs. LSU.
• Analysts Brad Crawford and Chris Hummer provide predictions for major games, noting tight betting lines and highlighting defensive strengths, offensive challenges, and recent team performances.
• Notable picks include Wake Forest favored over SMU due to strong run defense, Miami expected to overcome Duke with superior rushing defense, Ohio State projected to cover against Northwestern despite recent struggles, and Tennessee favored in a close game against Texas A&M.
• High-stakes games such as USC at Indiana and Texas at LSU are predicted to be competitive, with Indiana and LSU favored to win but with expectations of close contests and potential upsets.
• The top-ranked Georgia team is favored to defeat Missouri comfortably, while Utah is expected to maintain an undefeated season against Arizona; Kentucky is seen as a slight favorite over Florida in a must-win for CFP hopes.