College football odds, predictions, picks, Week 3 betting guide

Key Points:

• Week 3 of college football features a marquee top-10 matchup with No. 8 Ole Miss hosting No. 7 LSU in Oxford, Miss., where LSU is favored by 3 points and quarterback Sam Leavitt is back from injury.
• This game is the only top-10 matchup available for betting this week, with home teams having won the last six meetings between these squads.
• Other notable games include No. 2 Georgia vs. Arkansas, No. 12 USC vs. Rutgers, No. 10 Alabama vs. Florida State, and No. 25 Virginia vs. West Virginia, offering a mix of conference and non-conference matchups.
• SportsLine’s advanced model, which simulates each FBS game 10,000 times and has a strong 33-21 record on money-line picks this season, recommends South Carolina (-3.5) to cover against Mississippi State and Michigan State (+28.5) to stay within the spread against Notre Dame.
• Bettors are encouraged to use trusted promo codes like CBSSPORTS for bonuses on platforms such as Polymarket and Kalshi, and to consult SportsLine for comprehensive picks and predictions for every Week 3 game.