College football odds, schedule, picks: Week 1 predictions, best bets today

Key Points:

• The 2026 college football Week 1 schedule features 90 FBS games, highlighted by Lane Kiffin's LSU debut against Clemson, with LSU favored by 10.5 points, and a ranked matchup of No. 9 Ole Miss vs. No. 24 Louisville on Sunday.
• Ohio State, the No. 1 team, opens its season heavily favored (-50.5) at home against Ball State, while other notable non-conference games include UCLA vs. Cal and Baylor vs. Auburn.
• A SportsLine computer model, which simulates each FBS game 10,000 times and has a strong record on money-line picks, recommends Auburn (-7.5) to cover against Baylor and Cincinnati (-7.5) to cover against Boston College, citing team performance trends and player strengths.
• The model also predicts a Big Ten team will suffer a shocking upset in Week 1, with full picks and betting insights available exclusively on SportsLine.
• Key Week 1 odds include Rutgers favored by 28.5 over UMass, Oklahoma by 41.5 over UTEP, and Notre Dame by 20.5 over Wisconsin, with spreads and totals subject to change.