Convergent MurJ flippase inhibition by phage lysis proteins
Nature • • general
Key Points:
- The global burden of bacterial antimicrobial resistance (AMR) has been extensively analyzed, showing increasing challenges from 1990 through 2021 with forecasts predicting worsening scenarios by 2050, emphasizing the urgent need for new antibiotics and strategies (Murray et al., 2022; Naghavi et al., 2024).
- Bacterial cell wall biosynthesis, particularly the lipid II flippase MurJ, remains a critical and attractive target for novel antibiotic development due to its essential role in peptidoglycan assembly and bacterial viability (Bugg et al., 2011; Lovering et al., 2012; Sham et al., 2014).
- Recent structural and mechanistic studies of MurJ reveal its alternating
