Humans could theoretically live up to 156 years, study says
Key Points:
- Scientists at the Skolkovo Institute of Science and Technology used a model to estimate the maximum human lifespan if all aging factors except somatic mutations were eliminated.
- Somatic mutations are DNA changes in cells after conception that can lead to genetic conditions affecting health, according to the Cleveland Clinic.
- The study found that non-dividing cells like neurons and heart cells limit lifespan to about 156 years due to somatic mutations, compared to a theoretical non-aging baseline of 1759 years.
- Proliferating tissues such as the liver can maintain function for thousands of years by replacing cells, reducing mutation impact on aging.
- Researchers concluded that while somatic mutations significantly contribute to aging, other aging mechanisms also play important roles in determining human lifespan, potentially allowing lifespans of 146–194 years.