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Humans Have a Third Set of Teeth. New Medicine May Help Them Grow.
Yahoo • • health
Key Points:
- Japanese researchers are developing a drug, TRG035, that targets the USAG-1 protein to stimulate natural tooth regrowth, potentially offering an alternative to implants and dentures.
- Animal studies have shown success in growing new teeth by blocking USAG-1, and a Phase I human trial in Japan has been completed, focusing primarily on safety in adults missing molars.
- The initial human treatment focus is on rare congenital conditions where multiple permanent teeth are missing, rather than common tooth loss from decay or injury.
- Despite promising early results and significant funding, including $5.3 million raised in 2026, the drug has yet to prove it can regrow fully functional human teeth.
- Toregem BioPharma aims for practical clinical use of the tooth-regrowth drug by 2030, but further trials and evidence are needed to confirm its effectiveness and safety.
