In step toward immortality, Israeli scientists say they can 'rewind' aging in mouse livers

Key Points:

• Researchers from Bar-Ilan University, the US National Institute on Aging, and Tel Aviv University have reversed key signs of age-related liver decline in older mice by increasing levels of the longevity protein SIRT6, as published in Nature Communications.
• The study demonstrated that boosting SIRT6 reorganizes chromatin structure in liver cells, effectively "rewinding" DNA organization to a younger state and reducing harmful inflammation linked to aging.
• SIRT6 plays a crucial role in DNA repair, metabolic control, and aging regulation, with prior research by Prof. Haim Cohen showing that augmenting SIRT6 levels can extend life expectancy in mice.
• Experts highlight that these findings suggest aging may be more reversible than previously thought, with potential implications for improving human healthspan and longevity through targeted SIRT6 therapies.
• The research builds on ongoing efforts to harness biological mechanisms found in long-lived mammals, aiming to develop treatments that enhance healthy aging in humans by restoring SIRT6 activity.