Joe Manganiello reveals life-threatening health battle resulting in 'amputation'

Key Points:

• Joe Manganiello revealed in his upcoming memoir "Bloodlines" that he suffered from life-threatening autoimmune-related illnesses affecting multiple organs, which led to a life-saving amputation.
• During a seven-year battle with chronic pain and unexplained symptoms, doctors struggled to diagnose him, prompting Manganiello to explore unconventional treatments including shamans, pagan rituals, and spirituality.
• In researching his family history, Manganiello discovered ancestors who survived the Armenian genocide and chronic illnesses, which influenced his healing journey and perspective on suffering.
• Manganiello described this period as the most difficult yet transformative time of his life, hoping his story will offer hope to others facing similar struggles.
• "Bloodlines" is scheduled for release on October 13, 2025; Manganiello recently got engaged to Catlin O’Connor after divorcing Sofía Vergara in 2024.