Kentucky vs Iowa State March Madness Predictions, Picks, 2026 NCAA Tournament odds (3/22)

Kentucky vs Iowa State March Madness Predictions, Picks, 2026 NCAA Tournament odds (3/22)

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Key Points:

  • The Kentucky Wildcats face the Iowa State Cyclones in the NCAA Tournament's second round, with tip-off at 2:45 p.m. ET on CBS; Iowa State is favored by 5 points.
  • Kentucky's Otega Oweh has been a standout player, scoring 35 points in the previous game, while Brandon Garrison has been strong defensively with multiple blocks in recent games.
  • Iowa State won convincingly in the first round but may be without star Joshua Jefferson due to an ankle sprain, which could impact their offensive performance.
  • Kentucky's guard play has been inconsistent, and the team will need Collin Chandler to regain his scoring form to overcome Iowa State's aggressive defense.
  • The expert prediction

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