Lions vs. Bills prediction: Preview, odds, streaming for Thursday night

Key Points:

• The Buffalo Bills host the Detroit Lions in the first-ever game at the new Highmark Stadium on Thursday, Sept. 17, at 8:20 p.m. ET, with the game streaming on Amazon Prime and available via the CBS Sports App.
• Both teams showed strong offensive performances in Week 1, with the Bills scoring 36 points against Houston and the Lions scoring 31 points in an overtime win against New Orleans, setting expectations for a high-scoring game with an Over/Under of 54.5 points.
• Key players to watch include Josh Allen, who had a standout game last week with two passing and two rushing touchdowns, and Jahmyr Gibbs, who is expected to be the Lions' primary offensive weapon after a heavy workload in Week 1.
• The Lions will face challenges on the offensive line due to injuries to left guard Christian Mahogany and right tackle Blake Miller, potentially impacting their ability to protect quarterback Jared Goff against a strong Bills defensive front.
• The prediction favors a close, high-scoring contest with the Bills winning 35-31, though the Lions are expected to keep the game competitive and prevent the Bills from covering the spread.