MLB Predictions, Odds and Expert Picks for Opening Day on Thursday, March 26

Key Points:

• Sean Zerillo's Opening Pitch column offers MLB betting predictions and expert picks for Thursday, March 26, focusing on moneylines and totals for key matchups including Twins-Orioles, Diamondbacks-Dodgers, and Guardians-Mariners.
• The Twins are favored as a value moneyline pick against the Orioles, with projections highlighting Minnesota's strong offense against left-handed pitching and pitcher Joe Ryan's edge over Trevor Rogers; the Over 8 runs is also recommended due to favorable weather conditions.
• For the Diamondbacks vs. Dodgers game, the Over 9 runs is advised, supported by the Dodgers' potent lineup and warm weather, while a prop bet on Yoshinobu Yamamoto recording under 16.5 outs is suggested due to expected limited pitch count.
• The Guardians vs. Mariners game is projected as a low-scoring contest with a recommended Under 6.5 total, considering Seattle's historically pitcher-friendly conditions and strong bullpen, despite the Mariners' offensive depth.
• Additional picks include unders for Angels/Astros and Nationals/Cubs games, overs for Pirates/Mets and Twins/Orioles, and a parlay on Red Sox and Tigers first five innings, with all bets accessible via various sportsbooks and the Action Network App.