Molecular system can distinguish and neutralize cancer cells, paving the way for 'smart' drugs
Phys.org • • health
Key Points:
- Researchers at the University of Geneva have developed a DNA-based "smart" system that precisely targets cancer cells by recognizing two specific cancer markers and releasing drugs only at tumor sites, minimizing damage to healthy tissue.
- This technology uses small synthetic DNA strands that can penetrate tumors more effectively than traditional antibody–drug conjugates, enabling higher drug payload delivery and improved treatment precision.
- The system operates like a molecular "and" logic gate, activating drug release only when both cancer biomarkers are present, thereby enhancing selectivity and reducing side effects.
- Laboratory studies showed successful selective targeting and drug delivery to cancer cells without harming nearby healthy cells, and the approach allows combining multiple therapeutics to potentially overcome drug resistance.
- This innovation represents a step toward programmable, "smart" medicines capable of complex decision-making within the body, paving the way for personalized, adaptive cancer therapies with fewer side effects.
