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New drug combo may preserve muscle during weight loss
Yahoo • • health
Key Points:
- A recent trial published in Nature indicates that apitegromab, when combined with tirzepatide, may help preserve lean body mass while promoting overall weight loss in adults with overweight or obesity.
- Apitegromab is a monoclonal antibody that inhibits myostatin, a protein that limits skeletal muscle growth, thereby helping maintain muscle mass during weight loss therapy.
- In a 24-week study of 102 participants, those treated with apitegromab and tirzepatide lost less lean mass and about 85% of their total weight loss came from fat compared to the placebo group.
- Adverse events occurred in 76% of the apitegromab group and 71% of the placebo group, with the study excluding individuals with diabetes, heart disease, stroke, vascular disorders, or active cancer.
