NFL Week 3 odds, predictions: Picks from 10,000 computer simulations

Key Points:

• Week 3 of the NFL features challenging travel schedules for some teams, including West Coast teams playing early on the East Coast and the Cowboys vs. Ravens game held in Rio de Janeiro, Brazil, marking the first NFL game in Rio.
• The Cowboys are 3.5-point underdogs against the Ravens despite being the designated home team in the Rio game, while the Bills are 7-point favorites over the Chargers, and the Seahawks are 7.5-point favorites against the Commanders.
• Washington will be without quarterback Jayden Daniels for an extended period due to an elbow injury, while Seattle's Sam Darnold is healthy and expected to play.
• SportsLine’s advanced computer model, which has a strong track record with over $7,000 in profits for $100 bettors since 2024, predicts the Lions (-6.5) will cover against the Jets and the 49ers (-8.5) will cover against the Cardinals in Week 3.
• The model offers comprehensive Week 3 NFL picks and betting advice, including five A-rated spread picks, available exclusively through SportsLine for bettors seeking data-driven predictions.