NFL Week 5 picks: Buccaneers at Cowboys, 49ers at Seahawks, Eagles at Jaguars

Key Points:

• Week 5 of the 2026 NFL season features key matchups including the Eagles vs. Jaguars in London, 49ers vs. Seahawks in Seattle, and Bills vs. Rams on Monday Night Football, with many games expected to be closely contested.
• The Dallas Cowboys are favored to beat the Tampa Bay Buccaneers, with both CBS Sports analysts predicting a Cowboys win due to their high-scoring offense and the Buccaneers' struggles on offense.
• The Jaguars are favored over the injury-plagued Eagles in London, though one analyst believes the Eagles can keep the game close despite their recent poor performance and key injuries.
• The Packers are slight favorites against the Bears, but predictions are split with one analyst expecting a Packers win and the other calling it a push due to Chicago's improved defense and backup quarterback.
• The 49ers-Seahawks game is seen as a potential game of the week, with the 49ers favored for an upset based on strong performances by Brock Purdy, while the Seahawks are also expected to compete closely due to their solid defense.
• Other notable picks include the Falcons favored over the Ravens without Lamar Jackson, the Steelers favored against the Colts due to rest advantage, and the Bills expected to upset the Rams on Monday Night Football despite recent turnover issues.