NFL Week 5 picks: Upset and score predictions, matchup breakdowns for every game

Key Points:

• Bobby favors the Cowboys over the Buccaneers due to Dallas' offensive firepower, particularly CeeDee Lamb's standout performance, despite Dallas' defensive struggles; Tampa Bay's limited passing and rushing yards make it difficult for them to keep pace.
• Jeremy picks the Jaguars against an injury-riddled Eagles team traveling to London, noting Jacksonville's strong defense and consistent offense, while Philadelphia faces key absences and challenges adapting to the UK environment.
• Gennaro highlights concerns with Bengals QB Joe Burrow's late-game turnovers and an injured receiving corps, suggesting a closer game against winless Miami despite Cincinnati's overall talent advantage.
• Brooke believes the Vikings will edge out the Saints due to Minnesota's superior offensive efficiency and a strong running game led by Aaron Jones, while New Orleans struggles with injuries and a high-pressure defense that could challenge the Saints' inexperienced QB.
• Dan expects the Bears' dominant rushing attack to control the game against the Packers, who have a weak run defense and recent key injuries, potentially allowing Chicago to dominate time of possession and capitalize on Green Bay's offensive struggles.