Scientists chart over 140,000 DNA loops to map human chromosomes in the nucleus
Phys.org • • science
Key Points:
- A comprehensive 3D map of human chromosome organization and folding within the cell nucleus has been published, revealing over 140,000 DNA looping interactions in human embryonic stem cells and fibroblasts.
- The study, part of the 4D Nucleome Project, used genomic assays and computational modeling to create 1,000 distinct 3D genome models and developed deep learning tools to predict genome folding from DNA sequences.
- Chromatin loops, formed by DNA looping around histone proteins and cohesin, are essential for gene regulation by bringing distant DNA regions into contact, influencing gene expression and cellular function.
- The research integrates multi-technique genomic data to map the 4D nucleome, providing insights into how genetic
