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Serving sulfur to boost anti-tumour immunity
Nature • • science
Key Points:
- Lobel et al. identified sulfur amino acid (Saa) metabolism as a key microbial metabolic pathway that enhances anti-tumor immunity in colorectal cancer.
- Using mouse models with diets mimicking low and high human Saa consumption, the study found that a high Saa diet reduced advanced neoplastic lesions and overall tumor weight.
- The high Saa diet selectively increased the abundance of the bacterium Mucispirillum schaedleri, which was inversely correlated with tumorigenesis in colon cancer.
- While M. schaedleri was not detected in human stool samples, it was present in colonic tissue biopsies across various stages of colorectal cancer, suggesting its mucus-associated habitat.
