The midlife milestone linked to higher Alzheimer’s risk in women
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The midlife milestone linked to higher Alzheimer’s risk in women

New York Post health

Key Points:

  • Women account for about two-thirds of Alzheimer’s disease cases, with menopause timing identified as a key factor influencing risk.
  • A study of over 2,600 women found that earlier menopause is linked to faster brain aging and earlier Alzheimer’s diagnosis, associated with changes in white matter responsible for memory and learning.
  • White matter deterioration begins during menopause, reducing cognitive protection, and factors like comorbidities, pregnancy history, and medications may also impact Alzheimer’s risk.
  • Hormone therapy, particularly estrogen-only treatment, has been associated with a 35% lower lifetime risk of developing Alzheimer’s in women.
  • Surgical menopause causes abrupt hormonal changes that may negatively affect cognitive function, but the precise role of estrogen in preventing Alzheimer’s progression remains unclear.

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