Week 3 NFL odds, picks, predictions: Computer model backs Lions and 49ers

Key Points:

• Week 3 of the NFL features several games potentially impacted by travel and time zone changes, including West Coast teams playing early afternoon games on the East Coast. Notably, the Chargers visit the Bills and the Seahawks visit the Commanders, with key injury concerns affecting Washington.
• The Cowboys and Ravens will play the first-ever NFL game in Rio de Janeiro, Brazil, with Dallas as 3.5-point underdogs despite being the home team, highlighting the unique travel challenges for both teams.
• SportsLine’s advanced computer model, which has a strong track record of profitable NFL picks since 2024, provides betting advice and predictions for every Week 3 game, simulating each matchup 10,000 times.
• Top model picks include the Lions covering a 6.5-point spread against the Jets, benefiting from rest and strong post-loss performance, and the 49ers covering an 8.5-point spread versus the Cardinals, with San Francisco dominating both offense and defense metrics.
• For comprehensive Week 3 NFL betting picks, including five A-rated spread picks, bettors are encouraged to visit SportsLine, where the model’s insights aim to maximize potential returns.