Alzheimer's research: Columbia doctors pinpoint where the disease begins
ABC7 New York • • health
Key Points:
- Researchers at Columbia's Alzheimer's Research Center are investigating the origins and progression of Alzheimer's disease, focusing on cellular dysfunction within the brain.
- Dr. Scott Small identifies the endosome, a critical cellular organelle likened to "Grand Central Station," as the initial site of defect leading to Alzheimer's-related disruptions.
- Experimental drugs aimed at repairing these cellular defects have shown promise in preclinical studies, though human trials have yet to commence.
- Dr. Yasir Qureshi's work with mouse models and postmortem human brains demonstrates the potential to reverse cellular abnormalities, supporting the prospect of developing effective treatments.
- The research team is optimistic about a forthcoming breakthrough in Alzheimer's treatment, anticipating significant advances within the next few years.
