College football odds, lines, predictions, picks, Week 3 betting guide

Key Points:

• Week 3 college football features a marquee top 10 matchup as No. 8 Ole Miss hosts No. 7 LSU in Oxford, with LSU favored by 3 points; the last six meetings between these teams have been won by the home side.
• Several notable games mark the start of conference play, including No. 2 Georgia vs. Arkansas (+24.5) and No. 12 USC vs. Rutgers (+23.5), alongside key non-conference matchups like No. 10 Alabama vs. Florida State (+19.5).
• SportsLine’s advanced model, which has a 33-21 record on top-rated money-line picks since 2024 and has been upgraded for 2026, provides simulations and betting picks for every FBS game this week.
• Top model picks include South Carolina (-3.5) to cover against Mississippi State, backed by strong recent performance and defensive stats, and Michigan State (+29.5) to keep the game close against No. 3 Notre Dame.
• Bettors are encouraged to consult SportsLine for comprehensive Week 3 picks, including potential upsets and spread covers, supported by data-driven analysis and real-time odds updates.