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College football odds, prediction, best Week 1 picks today
CBS Sports • • general
Key Points:
- The 2026 college football Week 1 schedule features 90 FBS games, highlighted by Lane Kiffin's LSU debut against Clemson, with LSU favored by 10 points, and a ranked matchup of No. 9 Ole Miss vs. No. 24 Louisville on Sunday.
- Other notable non-conference games include UCLA vs. Cal, Baylor vs. Auburn at a neutral site in Atlanta, Notre Dame vs. Wisconsin at Lambeau Field, and SMU at Florida State to close the weekend.
- SportsLine's advanced model, which simulates each FBS game 10,000 times and has a strong 32-19 record on top-rated money-line picks since 2024, provides detailed Week 1 predictions and betting insights, including Auburn favored over Baylor and Cincinnati favored over Boston College.
- The model highlights Auburn's edge due to new QB Byrum Brown's dual-threat capabilities and Cincinnati's home advantage against a struggling Boston College team, recommending both to cover their spreads with potential for high-scoring games.
- Comprehensive Week 1 picks, odds, and predictions are available exclusively via SportsLine, including forecasts of potential upsets and spread covers across the full slate of games.
