Detroit Lions vs. Buffalo Bills preview, prediction: On Paper

Key Points:

• The Detroit Lions face the Buffalo Bills on Thursday night, with both teams coming off Week 1 wins; Buffalo had a more convincing victory, while Detroit nearly lost a 21-point lead.
• The Lions' passing offense showed some inconsistency in Week 1 but is generally strong, though concerns remain about right tackle Larry Borom replacing Blake Miller against a Bills pass rush led by Greg Rousseau.
• Buffalo's run defense struggled last year but showed some improvement in Week 1, while Detroit's rushing attack looked efficient, making the Lions favored in the ground game matchup.
• The Bills boast a top-tier passing offense led by Josh Allen and new receiver DJ Moore, posing a significant challenge to Detroit's pass defense, which allowed several big plays last week.
• The prediction favors the Bills to win 34-24, with Allen’s aggressive playstyle expected to exploit Detroit’s defensive vulnerabilities, while Detroit’s best chance lies in controlling the clock and executing a strong running game.