Eagles-Titans matchups to watch in Week 2

Key Points:

• The Eagles will face a significant challenge on their offensive line without Landon Dickerson, who is sidelined for at least four weeks, as they must contend with Titans' star defensive tackle Jeffery Simmons, a four-time Pro Bowler and recent highest-paid defensive tackle.
• Saquon Barkley struggled against Washington's run defense in Week 1 but may find more opportunities against the Titans, whose run defense ranked 15th last season and showed vulnerabilities by allowing 152 rushing yards to the Jets in their opener.
• DeVonta Smith, who had limited involvement in Week 1, could exploit the Titans' average cornerbacks, as Tennessee lacks an elite cornerback and allowed significant downfield passing yards recently.
• Cooper DeJean, recovering from injuries after a tough Week 1, will need to contain the Titans' slot receivers, including first-round pick Carnell Tate, who may see increased slot usage against him.
• The Eagles' defensive line faces a less experienced Titans offensive line with notable weaknesses, while defensive coordinator Vic Fangio aims to leverage his experience against young quarterback Cam Ward, who showed limited mobility and rushing ability in his early career.