Giants vs. Rams prediction, odds: 'Monday Night Football' NFL picks from proven model
Key Points:
- The New York Giants, coming off a 28-20 win over the Dallas Cowboys, will face the Los Angeles Rams, who lost 27-7 to the San Francisco 49ers, in Monday Night Football at SoFi Stadium.
- Rams star Aaron Donald returns after missing the opener, but Los Angeles will be without Myles Garrett due to a knee injury, and Puka Nacua is inactive with a hip issue.
- The Rams are favored by 6.5 points with an over/under of 47.5 points; recent trends and simulations suggest the game will go over the total points line.
- SportsLine's projection model, which has a strong track record with NFL picks, predicts a combined score around 49 points and indicates the over will hit slightly more than half the time.
- Giants QB Jaxson Dart and RB Cam Skattebo showed strong performances in Week 1, while Rams QB Matthew Stafford, despite a slow start, is coming off an MVP-caliber season.