Lions vs. Bills 'Thursday Night Football' betting odds, picks and predictions: Best bets, player props

Key Points:

• The Buffalo Bills (1-0) host the Detroit Lions (1-0) at Highmark Stadium in a Thursday night game featuring two high-powered offenses but struggling defenses, setting the stage for a likely high-scoring shootout.
• Buffalo started strong with a 36-31 win over the Texans, led by Josh Allen's 334 yards passing and four total touchdowns, while Detroit narrowly escaped an overtime win against the Saints after blowing a 21-0 lead.
• Both teams' defensive weaknesses are expected to be a major factor, with offenses likely to dominate, continuing the trend from their previous high-scoring 48-42 meeting earlier this year.
• Key player props include Josh Allen rushing for 30+ yards, wide receiver Keon Coleman bouncing back with significant receiving yards, and tight ends Dalton Kincaid and Sam LaPorta poised to exploit defensive mismatches and potentially score touchdowns.
• Detroit's defensive struggles against tight ends and Buffalo's heavy utilization of Kincaid suggest the tight end matchup will be critical, with both Kincaid and LaPorta expected to have strong performances.