
Many people who come off GLP-1 drugs regain weight within 2 years, review suggests
Key Points:
- A review by University of Oxford researchers found that many people regain weight within two years after stopping GLP-1 weight loss drugs, with weight regain occurring faster than after lifestyle-based weight loss programs.
- GLP-1 medications like Ozempic and Wegovy mimic a natural hormone that reduces appetite and slows digestion, but stopping these drugs can lead to rapid weight regain due to reduced natural GLP-1 production and sensitivity.
- Experts caution that weight regain is common across all weight loss methods, but reliance solely on GLP-1 drugs without behavioral changes can make maintaining weight loss more challenging.
- Long-term conclusions about weight regain after stopping GLP-1 drugs are based on projections rather than extensive observed data, highlighting the need for ongoing nutritional









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