Many people who come off GLP-1 drugs regain weight within 2 years, review suggests

Many people who come off GLP-1 drugs regain weight within 2 years, review suggests

CNNhealth

Key Points:

  • A review by University of Oxford researchers found that many people regain weight within two years after stopping GLP-1 weight loss drugs, with weight regain occurring faster than after lifestyle-based weight loss programs.
  • GLP-1 medications like Ozempic and Wegovy mimic a natural hormone that reduces appetite and slows digestion, but stopping these drugs can lead to rapid weight regain due to reduced natural GLP-1 production and sensitivity.
  • Experts caution that weight regain is common across all weight loss methods, but reliance solely on GLP-1 drugs without behavioral changes can make maintaining weight loss more challenging.
  • Long-term conclusions about weight regain after stopping GLP-1 drugs are based on projections rather than extensive observed data, highlighting the need for ongoing nutritional