Mitochondria directly interact with the nuclear pore complex

Key Points:

• The references encompass foundational and recent studies on mitochondria interactions with other organelles such as the endoplasmic reticulum, nucleus, lysosomes, peroxisomes, lipid droplets, and vacuoles, highlighting their roles in cellular metabolism, signaling, and homeostasis.
• Several studies focus on mitochondrial dynamics, including transport in neurons, bioenergetics specialization in muscle, and mitochondrial retrograde signaling mechanisms influencing gene expression and cellular stress responses.
• Research on nuclear pore complex components like RanBP2 and their involvement in protein transport, metabolic regulation, and mitonuclear communication is well represented, emphasizing their importance in cellular function and proteostasis.
• Methodological advances are included, such as proximity-based protein labeling, proteomics data analysis tools, nucleosome positioning during differentiation, and computational approaches for protein structure prediction and phylogenetics, reflecting integrative techniques in cell biology.
• The collection also references protocols and tools for imaging, metabolomics, transcriptomics, and bioinformatics, indicating a comprehensive approach to studying mitochondrial biology and its impact on development, disease, and cellular metabolism.