New flu vaccine 2026: is the mRNA shot better than standard options?

Key Points:

• The FDA approved the Moderna mRNA flu vaccine (mFLUSIVA) for people aged 50-64, with expedited approval pending for those 65 and older; it offers somewhat better protection against dangerous influenza A strains compared to standard vaccines.
• The mRNA vaccine has mild to moderate side effects such as sore arm, fever, fatigue, and muscle aches, but no increase in serious adverse events; it was not tested in immunocompromised individuals or pregnant/breastfeeding women.
• Dr. Roach recommends getting the flu vaccine between late October and late November for optimal protection during flu season, and advises not to delay vaccination if the new mRNA vaccine is unavailable.
• Pregnant women should take precautions to avoid cytomegalovirus (CMV) infection or reinfection, including thorough handwashing and avoiding sharing utensils or kissing children on the lips, as natural immunity does not fully protect against CMV.
• While waiting until age 50 to get the mRNA flu vaccine is reasonable, timely vaccination with any approved flu vaccine is more important for effective flu season protection.