NFL odds, lines, predictions for Week 6: Picks from 10,000 computer simulations
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NFL odds, lines, predictions for Week 6: Picks from 10,000 computer simulations

CBS Sports • • general

Key Points:

  • Week 6 NFL features several divisional matchups, including Ravens vs. Browns (+5.5), Patriots vs. Jets (+7), Rams vs. Cardinals (+12.5), and Chiefs vs. Chargers (+8.5), with the Chiefs coming off a bye and having a 1-5 ATS record after byes in recent years.
  • The Patriots are favored by 7 points over the Jets, with a strong recent performance and a high likelihood to cover the spread according to SportsLine's model, which simulates games 10,000 times for betting predictions.
  • The Cardinals (+12.5) are also predicted to cover against the Rams, benefiting from a strong away underdog record and the Rams' negative turnover differential.
  • The Bills are the biggest road favorite at -4.5 against the Raiders, and several games have high over/under totals, including the Packers vs. Cowboys with an O/U of 53.
  • SportsLine's advanced computer model, with a track record of over $5,000 profit for $100 players since 2024, provides comprehensive Week 6 NFL picks and betting advice, highlighting five teams with over 70% chance to win and cover the spread.

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