NFL score predictions: Best bets, picks for Week 1 from elite expert
CBS Sports • • sports
Key Points:
- Bettors can place high-risk, high-reward exact score predictions for Week 1 NFL games, with potential payouts ranging from +6000 to +15000, such as for the Chiefs vs. Broncos Monday night matchup.
- SportsLine expert Eric Cohen, who finished the 2025-26 season with a 66% straight-up record, provides detailed Week 1 NFL score predictions and betting advice based on thorough analysis of the entire slate.
- Cohen recommends backing the Houston Texans (+1.5, 44.5 total) to narrowly defeat the Buffalo Bills, citing Houston's strong defense and historical trends where Texans have won four of the last five meetings by a single possession.
- He highlights Buffalo QB Josh Allen’s struggles in road games, especially against strong defenses like Houston’s, which sacked him eight times and intercepted him twice last year.
- Cohen also predicts a road team to win by double digits in Week 1, emphasizing the value of alternate betting lines for profitable NFL picks, with full predictions available exclusively at SportsLine.
