NFL Week 2 odds, predictions: Picks, best bets from 10,000 computer simulations

Key Points:

• The Rams and 49ers, coming off their international games in Australia, both have home games in Week 2, with the 49ers favored by 13.5 points against Miami and the Rams favored by 7 points against the Giants.
• SportsLine's advanced computer model, which simulates each NFL game 10,000 times, has a strong track record with over $7,000 profit for $100 bettors since 2024 and is providing Week 2 NFL picks and betting advice.
• The model strongly recommends the Seahawks (-4) to cover against Arizona, citing Seattle’s dominance over the Cardinals and their rest advantage, and also favors the Buccaneers (-8.5) to cover versus the Browns, highlighting Cleveland’s poor Week 1 performance and road record.
• The model has also identified an underdog likely to win outright by a touchdown and offers comprehensive picks for every Week 2 NFL game exclusively on SportsLine.
• Updated Week 2 NFL odds and betting lines reflect a trend of large spreads influenced by Week 1 results, with six games featuring at least a touchdown margin.