NFL Week 2 picks and score predictions: Bills top Lions in Thursday shootout, Seahawks suffer shocking loss

Key Points:

• The NFL season's first week saw surprising outcomes, including the Falcons leading their division without a win or quarterback, and unexpected victories for the Raiders, Jets, Giants, and Cardinals.
• Week 2 previews highlight key matchups: Bills vs. Lions is expected to be a high-scoring shootout, Buccaneers vs. Browns features Baker Mayfield seeking revenge against his former team, and the Cardinals are favored to upset the Seahawks despite low initial expectations.
• The Rams' travel to Australia is seen as negatively impacting their performance, with concerns that their season could be derailed; they face a tough schedule ahead and are predicted to narrowly beat the Giants in Week 2.
• Other Week 2 picks include the 49ers over the Dolphins, Panthers over Falcons, and Bengals continuing strong after a solid defensive showing in Week 1; overall, the Week 1 picks went 9-7 straight up and 6-10 against the spread.
• The Chargers continued their reputation for disappointing fans by eliminating millions of survivor pool entries, underscoring their ongoing struggles despite high expectations.