Orioles vs Royals Prediction, Odds, Start Time: MLB Pick for Wednesday, April 22
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Key Points:
- The Baltimore Orioles (11-13) will visit the Kansas City Royals (8-16) on April 22, 2026, with the Royals favored by -130 on the moneyline and -1.5 on the run line; the total runs are set at 9.5.
- Despite a struggling start with a 6.19 ERA and high walk rate, Orioles' pitcher Chris Bassitt remains strong in limiting hard contact, suggesting potential improvement if he reduces walks.
- The Orioles' lineup is slightly below average overall but boosted by the return of Adley Rutschman, who has a 146 wRC+, while the Royals have one of MLB's worst offenses, ranked 28th with an 83 wRC+.
- Veteran Royals starter Michael Wacha has a low ERA but underlying metrics suggest regression is likely, and Kansas City's hitting woes continue with key players underperforming significantly.
- The best bet is on the Orioles to win (+110 or better), as the pitching matchup and offensive potential favor Baltimore despite their recent struggles.
