Patriots vs. Seahawks prediction, odds, time: 2026 NFL Kickoff Game picks

Key Points:

• The 2026 NFL Kickoff Game will feature a rematch of the Super Bowl, with the Seattle Seahawks hosting the New England Patriots on Wednesday, September 9, marking the second time the game is not on a Thursday.
• Both teams finished the previous season with 14-3 records, with Seattle winning the Super Bowl 29-13 over New England; key injuries include Patriots RB TreVeyon Henderson (out) and Seahawks safeties Ty Okada (out) and Nick Emmanwori (questionable).
• Seattle is favored by 3 points with an over/under of 44.5 points; a SportsLine projection model, which simulates games 10,000 times, predicts the game will go over 44.5 points, projecting 46 combined points.
• The model highlights strong offensive upgrades for both teams, including New England adding All-Pro A.J. Brown and Seattle relying on rookie Jadarian Price due to injuries and departures in the backfield.
• The SportsLine model has a strong track record on NFL picks and suggests backing the over and one side of the spread with over 60% confidence, advising bettors to check its detailed predictions before wagering.