Protein restriction may boost longevity in sedentary adults, study finds

Key Points:

• A new scientific review published in Cell Press Blue suggests that reducing protein intake, rather than cutting calories, may offer similar metabolic benefits and promote a longer, healthier life for sedentary adults.
• Lower protein consumption was linked to improved metabolism, reduced cellular damage, and increased cellular maintenance, largely due to a hormone called fibroblast growth factor 21 (FGF21) that is triggered by protein restriction.
• The review highlights three amino acids—methionine, isoleucine, and valine—that may contribute to aging-related biological pathways, especially in inactive individuals, potentially causing cellular damage, inflammation, and weight gain.
• Researchers caution that protein needs vary by individual, emphasizing that physically active people, pregnant women, and older adults require higher protein intake for muscle growth and repair, and that public health guidelines should be tailored accordingly.
• As the review is based on existing studies rather than new clinical trials, further long-term human research is needed to confirm whether protein restriction directly extends lifespan.