Psilocybin Breaks Depressive Cycles by Rewiring The Brain, Study Suggests
ScienceAlert••health
Key Points:
- Scientists used an engineered rabies virus to track brain changes caused by psilocybin in mice, revealing it may break loops of depressive thinking by rewiring brain circuits.
- The study found psilocybin increased connectivity between sensory processing areas and action-related brain regions, while reducing connections within the cortex linked to negative thought feedback loops.
- These findings provide a potential explanation for psilocybin's positive effects in clinical trials for depression, suggesting it may weaken rumination, a key feature of the disorder.
- The research also indicates brain activity influences where psilocybin-induced rewiring occurs, raising the possibility of combining psychedelics with neuromodulation techniques for targeted treatment.
- While promising, these results need
