Scientists discover enzyme that could supercharge Ozempic-like weight-loss drugs
New York Post • • technology
Key Points:
- Scientists at the University of Utah have discovered an enzyme called PapB that can enhance popular peptide drugs like Ozempic and Wegovy by making them last longer and work faster through a process called macrocyclization.
- PapB "ties off" peptide drugs into tight ring shapes, increasing their stability, resistance to breakdown, and effectiveness in the body.
- This enzymatic modification could improve the performance of diabetes and weight-loss treatments, potentially leading to stronger and longer-lasting drug effects.
- Researchers believe the enzyme could also benefit other peptide-based medications used to treat gastrointestinal diseases and cancer tumors.
- Ozempic and Wegovy are injectable drugs that mimic a natural hormone to suppress appetite, slow digestion, and lower blood sugar, aiding in Type 2 diabetes management and significant weight loss.
