Something Grim Is Happening to People Who Go Off GLP-1s
Key Points:
- Many people who lose weight using Ozempic and other GLP-1 agonists struggle to stop the medication due to intense returning hunger and subsequent weight regain, suggesting potential lifelong dependency.
- Research shows that patients who discontinue these drugs often regain about two-thirds of their lost weight, with some physicians observing 60-80% weight regain after stopping treatment.
- Celebrities like Oprah plan to remain on these medications indefinitely, likening their use to managing chronic conditions such as high blood pressure.
- Experts recommend developing an "exit strategy" by adopting healthier lifestyle habits while on the drugs to help sustain weight loss after discontinuation.
- Some patients, like Ellen Ogley, have successfully maintained weight loss after stopping GLP-1











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