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Stripped-down LSD reveals structural features linked to hallucinogenic and therapeutic effects
Phys.org • • health
Key Points:
- UC Davis researchers have simplified LSD's complex molecular structure, creating new compounds that reduce hallucinogenic and cardiotoxic effects while retaining therapeutic potential.
- The study focused on LSD's ergoline core, identifying that phenethylamine-like traits are crucial for hallucinogenic effects, whereas removing certain parts can diminish negative side effects.
- Among nine synthesized derivatives, two compounds, UCD0094 and UCD0076, showed improved safety profiles; notably, UCD0076 demonstrated antipsychotic-like effects in mouse models by preferentially binding to the 5-HT2C receptor.
- This research offers new molecular frameworks for developing safer psychedelic-based therapeutics targeting neuropsychiatric and neurodegenerative diseases.
