Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers

Key Points:

• The Rams and 49ers, both having played in Australia last week, will be closely watched in their Week 2 home games against the Giants and Dolphins respectively, with the 49ers favored by 13.5 points, the largest spread so far this season.
• The Rams are also heavy favorites, giving 7.5 points to the Giants, and these matchups are among six games with spreads of at least a touchdown, reflecting adjustments by oddsmakers after Week 1.
• SportsLine's advanced computer model, which simulates each game 10,000 times and has a strong track record since 2024, has released its Week 2 NFL picks, including Seahawks (-4) to cover against the Cardinals and Buccaneers (-8.5) to cover versus the Browns.
• The model highlights Seattle's strong historical performance against Arizona and the Browns' poor road ATS record as key factors in its predictions, with over 50% confidence in Tampa Bay covering and the Over hitting in that game.
• For comprehensive Week 2 NFL picks and betting advice based on this proven model, bettors are encouraged to visit SportsLine, which offers detailed predictions on all matchups and potential underdog winners.