What the HECK is NAD? (And Should You Be Taking It?)

Key Points:

• NAD (nicotinamide adenine dinucleotide) is a molecule essential for cellular energy production, DNA repair, and cellular communication, with levels naturally declining with age and stress.
• Supplementation methods include oral tablets, injections, and IVs, but oral NAD is poorly absorbed, and most evidence supporting NAD benefits comes from small or animal studies, with limited large-scale human data.
• Ideal candidates for NAD supplementation are those with persistent fatigue, midlife metabolic changes, or high-performing individuals already following a comprehensive wellness plan; it is not recommended as a quick fix or for people with active cancer or certain chronic diseases.
• Experts emphasize lifestyle factors like sleep, diet, exercise, and stress management as primary ways to support NAD levels, recommending supplementation only after these foundations are addressed and under medical supervision.
• Quality and sourcing of NAD supplements vary widely, and patients are advised to avoid unverified products from unreliable sources due to safety concerns and lack of regulation.