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Which GLP-1 works best? New meta-study puts them head-to-head
NewsNation • • health
Key Points:
- A University of Georgia study compared the effectiveness of three GLP-1 medications—tirzepatide, semaglutide, and liraglutide—in promoting weight loss among 14,000 non-diabetic patients.
- Tirzepatide (Zepbound and Mounjaro) showed the highest weight loss, with patients losing over 20% of their starting weight, compared to about 15% with semaglutide (Wegovy) and 8% with liraglutide (Saxenda).
- Tirzepatide acts as a dual agonist targeting both GLP-1 and GIP receptors, which may contribute to its superior effectiveness, while the other drugs target only GLP-1 receptors.
- The study also assessed side effects like nausea and gastrointestinal issues, finding tirzepatide to be a better option without higher rates of adverse effects.
- The research did not examine weight regain after stopping the medications, a known issue with GLP-1 treatments.
