Which group achieves 41% more weight loss on GLP-1s like Mounjaro

Key Points:

• A study published in the journal Obesity found that overweight or obese women taking tirzepatide (Mounjaro) lost significantly more weight than men, with women losing 15% of their body weight after 15 months compared to nearly 11% for men.
• Age influenced weight loss to a lesser extent, with participants under 45 losing more weight than those over 60, but factors like absence of Type 2 diabetes, no prior weight-loss medication use, and higher tirzepatide doses were also linked to greater weight loss.
• Women historically face more challenges losing weight due to physiological differences, yet studies show women tend to lose more weight than men on GLP-1 medications like tirzepatide and Ozempic, with gender being the strongest predictor of weight loss outcomes.
• Possible reasons for women's greater weight loss include slower drug clearance from the bloodstream and hormonal influences, particularly estrogen, which affects appetite, fullness, energy use, and insulin sensitivity.
• Beyond weight loss, Mounjaro may offer additional health benefits for women, although these were not detailed in the study.