Guardians vs White Sox Prediction, Home Run Pick & Odds: ALDS Game 3 MLB Picks

Key Points:

• The Chicago White Sox are favored to win Game 3 of the ALDS against the Cleveland Guardians, aiming for their first home playoff series victory since 1906, with the game starting at 4 p.m. ET on Oct. 7 at Rate Field.
• The White Sox continue to use an opener pitching strategy due to a shortage of quality starters, with Sean Newcomb starting Game 3 and key relievers like Grant Taylor, Bryan Hudson, and Jordan Hicks rested and ready.
• Cleveland will start Daniel Espino with Joey Cantillo likely following, but Chicago's offense, which has performed well against left-handed pitchers recently, is expected to have the advantage, especially in favorable weather conditions for home runs.
• Key player prop picks include Munetaka Murakami, who has strong power-hitting metrics post-All-Star break, and Jo Adell, Cleveland’s top hitter against lefties after the break, who is expected to perform well in better hitting weather.
• Weather conditions at Rate Field (74 degrees, 10 mph winds blowing out) are conducive to increased home runs, supporting predictions for a higher-scoring game with the over/under set at 7.5 runs.