NFL Thursday Night Football preview: Rams and 49ers go all the way to Australia for opener

Key Points:

• The NFL is hosting its first regular-season game in Australia, with the Los Angeles Rams and San Francisco 49ers playing in Melbourne, marking a significant international expansion effort. The teams took different travel approaches, with the 49ers arriving over a week early and the Rams arriving the day before the game.
• The matchup features two NFC West rivals, with the Rams considered Super Bowl favorites after key offseason acquisitions including Defensive Player of the Year Myles Garrett and the return of Aaron Donald (who will not play in this game). The 49ers, led by coach Kyle Shanahan, also boast strong talent including Brock Purdy and Christian McCaffrey.
• The Rams' travel strategy and performance will be closely scrutinized, as a loss could lead to second-guessing amid high expectations. Conversely, a win would reinforce their status as a top contender and set a positive tone for the season.
• Myles Garrett's debut with the Rams is highly anticipated, as he is coming off a record-setting season and is considered the NFL's top player. His impact on the game will be a major storyline, with the 49ers likely to devise plans to limit his influence.
• Betting perspectives are mixed regarding the travel schedules, but oddsmakers generally favor the Rams' approach. The game also presents fantasy football intrigue, with questions about offensive output in international games and the performance of aging 49ers players and Rams running backs.