NFL Week 1 picks: Upset and score predictions, matchup breakdowns for every game

Key Points:

• Dan expects a more competitive rematch between the Patriots and Seahawks due to Seattle's weakened run game and secondary, with rookie backs and injured defensive backs raising concerns against a Patriots offense led by Josh McDaniels.
• Bobby doubts the Rams' ability to overcome travel fatigue and injuries in their season opener against the 49ers, who arrived early to Australia for better acclimation; the 49ers hold a slight edge in the Shanahan-McVay coaching rivalry.
• Dan favors the Bears over the Panthers, citing skepticism about Bryce Young's offense and believing Chicago's offense under Ben Johnson can outscore Carolina despite defensive concerns on both sides.
• Bobby picks the Bengals to edge the Buccaneers in an explosive Week 1 matchup, banking on a healthy Joe Burrow and a strong receiving corps to capitalize on Tampa Bay's post-Mike Evans transition.
• Gennaro selects the Lions over the Saints at home, highlighting Detroit's high-scoring offense and New Orleans' defensive weaknesses, with Lions' new OC Drew Petzing poised for a strong debut.