NFL Week 2 odds, predictions: Picks, best bets from 10,000 computer simulations

Key Points:

• The Rams and 49ers, returning from their international game in Australia, both have home games in Week 2, with the 49ers favored by 13.5 points and the Rams by 7.5 points, reflecting significant spreads influenced by Week 1 outcomes.
• SportsLine's advanced computer model, which simulates each NFL game 10,000 times, has a strong track record since 2024, with over $7,000 in winnings for $100 players and a current 53-39 run on top-rated picks.
• Key Week 2 predictions include the Seahawks covering a 4-point spread against the Cardinals, with a nearly 60% probability, and the Buccaneers covering an 8.5-point spread against the Browns, with over 50% forecasted coverage and a strong chance for the Over.
• The model also identifies an underdog expected to win outright by a touchdown, offering a potential high payout, and provides comprehensive picks for every Week 2 NFL game available exclusively on SportsLine.
• Fans and bettors are encouraged to review the latest NFL odds and betting advice on SportsLine, utilizing promo codes like CBSSPORTS for bonuses on platforms such as Polymarket and Kalshi.