NFL Week 3 odds, predictions: Picks from 10,000 computer simulations

Key Points:

• Week 3 NFL schedule features significant travel challenges, including West Coast teams playing early games on the East Coast and the Cowboys vs. Ravens game held in Rio de Janeiro, Brazil, marking the first NFL game in the city.
• The Cowboys are 3.5-point underdogs despite being the designated home team in the Rio game, while Buffalo is favored by 7 points over the Chargers, and Seattle is a 7.5-point favorite against Washington.
• SportsLine's advanced computer model, which simulates each game 10,000 times, has a strong track record with over $7,000 profit on $100 bets and a 53-41 run on top-rated picks since 2024.
• Key model predictions include the Lions covering a 6.5-point spread against the Jets, leveraging their strong performance after losses, and the 49ers covering an 8.5-point spread against the Cardinals, with San Francisco expected to win by double digits.
• For comprehensive Week 3 NFL picks and betting advice, including five A-rated spread picks, bettors are encouraged to visit SportsLine for the latest odds and model-driven recommendations.